I-A4 Protein Precursor₇₇₀ (740-770) trifluoroacetate ityuwa/1802086-24-3/GT Peptide/Peptide Supplier

Inkcazo

I-amyloidβ/ A4 protein precursor (740-770) ihambelana neC-terminal amyloid precursor protein (APP) fragment ebizwa ngokuba yiC31.Esi siqwenga siveliswa nge-intracellular nge-proteolytic cleavage ye-APP nge-caspases-8 kunye ne-9.I-C31 ineempembelelo ze-pro-apoptotic kunye ne-cytotoxic kwiiseli ze-neuronal kwaye ibonakaliswe ukuba ikhona kwiingqondo ze-Alzheimer's disease (AD) izigulane.Kwiiseli ezikhuliswayo, i-caspase cleavage ye-APP yenziwa yi-amyloid beta protein, kwaye imveliso elandelayo ye-C31 ikhokelela ekufeni kweeseli ze-apoptotic ezinxulumene ne-amyloid beta protein.I-Amyloid precursor ebopha iprotheyini ye-BP1 (APP-BP1), i-cyclin eyonyuswa kwingqondo ye-AD, iboniswe ukuba ibophe kwi-C31 kummandla we-APP kunye nokudibanisa i-apoptosis eyenziwe yi-APP.

Iinkcukacha

Imbonakalo: Imhlophe ukuya kumgubo omhlophe

Ubunyulu(HPLC):≥98.0%

Ukungacoceki okukodwa:≤2.0%

Umxholo we-Acetate(HPLC): 5.0%～12.0%

Isiqulatho samanzi (uKarl Fischer):≤10.0%

Umxholo wePeptide:≥80.0%

Ukupakisha kunye nokuThumela: Ukushisa okuphantsi, ukupakisha i-vacuum, ngokuchanekileyo kwi-mg njengoko kufuneka.

Ungaodola Njani?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Oda kwi-intanethi.Nceda ugcwalise ifom ye-odolo ye-intanethi.

3. Nika igama le-peptide, inombolo ye-CAS okanye ulandelelwano, ukucoceka kunye nokuguqulwa ukuba kuyimfuneko, ubungakanani, njl.njl. siya kubonelela ngekowuteshini kwiiyure ezi-2.

4. Umyalelo wokuthotyelwa kwemvumelwano yokuthengisa esayiniweyo ngokufanelekileyo kunye ne-NDA (isivumelwano esingaveziyo) okanye isivumelwano esiyimfihlo.

5. Siya kuqhubeka sihlaziya inkqubo ye-odolo ngexesha.

6. Ukuhanjiswa kwePeptide yi-DHL, Fedex okanye abanye, kunye ne-HPLC, MS, COA iya kubonelelwa kunye nomthwalo.

7. Umgaqo-nkqubo wembuyekezo uya kulandelwa ukuba kukho ukungangqinelani komgangatho okanye inkonzo yethu.

8. Inkonzo emva kokuthengisa: Ukuba abathengi bethu banemibuzo malunga nepeptide yethu ngexesha lovavanyo, nceda uzive ukhululekile ukuqhagamshelana nathi kwaye siya kuyiphendula ngexesha elifutshane.

Zonke iimveliso zenkampani zisetyenziselwa kuphela injongo yophando lwesayensi, yona'Ithintelwe ukuba isetyenziswe ngokuthe ngqo nguye nawuphi na umntu emzimbeni womntu.

FAQ:

Sesiphi isiphelo esilungileyo kuphando lwam?

Ngokungagqibekanga, i-peptide iphela nge-N-terminal yasimahla ye-amino iqela kunye ne-C-terminal yasimahla ye-carboxyl iqela.Ulandelelwano lwepeptide luhlala lubonisa ukulandelelana kweprotein kamama.Ukuze ube kufutshane neprotheni yomama, ukuphela kwepeptide kaninzi kufuneka kuvalwe, oko kukuthi, i-n-terminal acetylation kunye ne-C-terminal amidation.Olu hlengahlengiso luthintela ukuqaliswa kwentlawulo engaphezulu, kwaye lukwenza kube lula ukuthintela isenzo se-exonucliase, ukuze i-peptide izinze ngakumbi.

Zeziphi iipolypeptides ezilungisiweyo ezinophawu olunokwenziwa kwipeptide yaseTshayina?

Inkampani yethu ibonelela ngeendlela ezahlukeneyo zokubhalwa kwe-peptide elungisiweyo, efana ne-acetylation, ilebhile ye-biotin, ukuguqulwa kwe-phosphorylation, ukuguqulwa kwe-fluorescence, kunokwenziwa ngokwezifiso ngokweemfuno zakho ezizodwa.

Uzinyibilikisa njani iipolypeptides?

I-solubility ye-polypeptide ixhomekeke kakhulu kwisakhiwo sayo esisisiseko kunye nesesibini, uhlobo lwelebula yokuguqulwa, uhlobo lwe-solvent kunye noxinzelelo lokugqibela.Ukuba i-peptide ayinyibiliki emanzini, i-ultrasound inganceda ukuyinyibilikisa.Kwi-peptide eyisiseko, kucetyiswa ukuba ichithe nge-10% ye-acetic acid;Kwi-peptides ene-acidic, ukuchithwa nge-10% NH4HCO3 kuyacetyiswa.Izinyibilikisi ze-Organic nazo zinokongezwa kwiipolypeptides ezinganyibilikiyo.I-peptide inyibilika kwixabiso elincinci le-solvent ye-organic (umzekelo, i-DMSO, i-DMF, i-isopropyl alcohol, i-methanol, njl.).Kucetyiswa kakhulu ukuba i-peptide inyibilikiswe kwisinyibilikisi se-organic kuqala kwaye ngokucothayo yongezwe emanzini okanye kwesinye isithinteli kude kube kugxininiso olufunekayo.

Zeziphi ezona meko zilungileyo zogcino?Izinze kangakanani i-peptide?

Emva kwe-lyophilized, i-polypeptide inokwenza i-fluff okanye i-flocculant powder, enokuthintela ukuthotywa kwangaphambili kwe-polypeptide.Iimeko zokugcina ezicetyiswayo: a.-20℃indawo yokugcina okanye eyomileyo b.Zama ukunqanda ukunyibilika okuphindaphindiweyo c.Zama ukunqanda ukugcinwa kwimo yesisombululo (umgubo omiswe ngumkhenkce ungagcinwa kwiipakethe ezahlukeneyo ukulungiselela ukusetyenziswa lula) d.Ukuba kufuneka igcinwe kwisisombululo, kuyacetyiswa ukuba ichithe i-peptides emanzini angenanto phantsi kweemeko ezibuthathaka ze-asidi kwaye igcine kwi-20.℃.

Ithuthwa njani i-peptide yam?Zeziphi iingxelo zovavanyo ezinikiweyo?

Zonke iipolypeptides ezomisiweyo ezikhenkcezisiweyo zidla ngokugcinwa kwizikhongozeli ezikhethekileyo ze-2 ml okanye i-10ml eneenkcukacha zohlalutyo lwangaphambili kunye neengxelo ze-synthesis eziqulethe ulwazi olubalulekileyo olunjengokulandelelana, ubunzima bemolekyuli, ubunyulu, ubunzima, kunye nenani lepolypeptide.

Yintoni ubunzima obunzima?Yintoni umxholo wepeptide?

Emva kokuba i-lyophilized peptide iguquguquka kwaye ifana ne-fluff, isenokuthi iqulethe izixa zokulandela zamanzi, izinyibilikisi ezifakwe kwi-adsorbed kunye neetyuwa ngenxa yeempawu zepeptide ngokwayo.Oku akuthethi ukuba ukucoceka kwepeptide akwanele, kodwa ukuba umxholo wepeptide uyancipha nge-10% ukuya kwi-30%.Ubunzima bomnatha bepeptide bobona bunzima bepeptide thabatha amanzi kunye neeyoni ezineprotonated.Ukuqinisekisa ukuxinana kwepeptide, izinto ezingezizo iipeptide kufuneka zisuswe kwi peptide ekrwada.

Ingaba icoceke kangakanani i-peptide?

Inkampani yethu inokubonelela ngamanqanaba ahlukeneyo okucoceka ukuze abathengi bakhethe kuwo, ukusuka kwikrwada ukuya kwi> 99.9% yobunyulu.Ngokweemfuno zabathengi sinokubonelela ngokucoceka> 99.9% i-polypeptide ye-ultra-pure.