Intshayelelo emfutshane ye-tidulutide

Indlela yokwenza i-tidulutide Gattex (teduglutide)

I-Teduglutide yi-analogue yomntu yendalo ye-glucagon-like peptide-2 (GLP-2), i-peptide efihlwe ziiseli ze-L kwi-distal gut.I-GLP-2 yaziwa ngokuphucula ukuhamba kwegazi kwamathumbu kunye ne-portal kwaye inqanda ukukhutshwa kwe-asidi yesisu.Kwidigri ze-lu peptide kunye ne-peptide receptor 2 iisampulu zeglucagon, i-insulin-efana ne-insulin factor in intestinal endocrine cells, iiseli ze-epithelial zefiber ye-muscle, i-submucosa kunye ne-mynteric stands phakathi kwe-neurons yamathumbu.Ukusetyenziswa kwezi receptor kubangela ukukhutshwa kwendawo yeendaba ezahlukeneyo, kubandakanywa ne-insulin-efana ne-IGF (IGF) 1, i-cell growth factor formation nitrogen oxide kunye ne-cutin cell growth factor (KGF).

I-Tidulutide, i-glucagon-like peptide 2 (GLP-2) analogue, iyanciphisa ukukhupha isisu kunye ne-metabolism kwaye ilawula ukukhula, ukuveliswa kunye nokubuyiswa kweeseli zamathumbu emathunjini.I-Peptide inyuse inani elipheleleyo lezi seli, inokunyusa ukufunxa kwamathumbu amancinci, inciphise urhudo.Isifo samathumbu esifutshane kubantu abadala sinokunyangwa ngeklinikhi.Ichiza libe lichiza lokuqala elicetyiswayo kunyango olunqabileyo kodwa olubuthathaka kakhulu.

Intshayelelo emfutshane ye-tidulutide

Ifomula yekhemikhali yemolekyuli ye-tidulutide

Iiparamitha ezisisiseko

Igama: ye-c peptide (Teduglutide)

Inani: GT – F027

Inombolo ye-CAS: 197922-42-2

Ulandelelwano: His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn- Trp-Leu-Ile-Gln-Thr-Lys- Ile-Thr-Asp

Ifomula yemolekyuli: C164H252N44O55S

Ubunzima bemolekyuli: 3752.08248