Ngaba i-trifluoroacetyl tripeptide-2 inokulibazisa ukuguga?

Ngathi:

I-peptide yitsheyini yee-amino acids ezidityaniswe ngamabhondi e-peptide.Iipeptides zibandakanyeka ikakhulu kulawulo lweeproteni, i-angiogenesis, ukwanda kweeseli, i-melanogenesis, ukufuduka kweeseli, kunye nokudumba.Iipeptide zeBioactive zisetyenziswa kakhulu kwishishini lezithambiso kumashumi eminyaka akutshanje.Iipeptide zifuna ubunzima obuphantsi be-molecular (> 500 Da), ukwenzela ukunciphisa ukusabalalisa kwe-peptide phakathi kwe-epidermal layers, ukuzinza okuphezulu kunye nokunyibilika.Ukutyhubela iminyaka, uluntu lwezenzululwazi luye lwaphuhlisa iqhekeza elincinci kwaye lizinzile le-peptide yokwenziwa evuselela ukuveliswa kwe-collagen kunye nokunciphisa imibimbi yobuso kunye ne-pigmentation.I-Trifluoroacetyl tripeptide-2 (ulandelelwano: TFA-Val-Try-Val-OH) i-tripeptide synthesis, eyilwe njenge-matrix metalloproteinase kunye ne-elastase inhibitor.Izifundo ze-in vitro kukhuseleko lwe-ECM nge-trifluoro-acetyl tripeptide 2(TT2), ukuhlanganiswa kweproteoglycan kwintsebenziswano yeseli-matrix, kunye nefuthe kwi-progerin synthesis kwi-fibroblasts eqhelekileyo yabantu esele ichongiwe kutshanje njenge-co-inducer yeselula. ububele.Iziphumo zibonisa ukuba i-trifluoroacetyl tripeptide 2 inoluhlu olubanzi lweepropathi zokulwa nokuguga.Oku kunciphisa i-progerin synthesis, kwandisa imveliso yeproteoglycan, kwaye iyancipha i-collagen, ngaloo ndlela inciphisa imibimbi kunye nokuphucula ukuqina kwezicubu.Ukongeza, i-anti-wrinkling, i-anti-flow hanging kunye neziphumo zokuqinisa ulusu ziye zavavanywa kwizifundo zobuso ezimbini ze-vitro.I-Trifluoroacetyl tripeptide 2 ibonakaliswe ukuba inefuthe eliqhubekayo kwimibimbi, ukuqina, ukuqina, kunye nokuncipha.

Ngaba i-trifluoroacetyl tripeptide-2 inokulibazisa ukuguga?

Uphononongo lubonise ukuba i-cell senescence inxulumene ngokusondeleyo neProgerin.Ngokuguga, i-presenilin iqokelela ngakumbi nangakumbi emzimbeni, ekhokelela kwiziphene zenyukliya kunye nomonakalo weDNA, ekhokelela kuluhlu lokuguga kwesikhumba.I-Trifluoroacetyl tripeptide-2 i-tripeptide esebenzayo ye-Elafin, i-derivative ye-elastase inhibitor.Iyanciphisa iProgerin synthesis kwaye iphucula ukutyeba kwesikhumba, ukugoba kunye nemibimbi.

Inkqubo

1. Ukuthintela ukuhlanganiswa kweProgerin ukulibazisa i-cell senescence.

2. Ukukhuthaza imveliso ye-syndecan kunye nokwandisa ubomi beeseli.

3. Ukuthintela umsebenzi we-matrix metalloproteinases i-MMP1, i-MMP3 kunye ne-MMP9, ukunciphisa ukuchithwa kweeprotheni ze-matrix ezingaphandle kunye nokugcina ingqibelelo yazo.

4. Ukuthintela umsebenzi we-elastase, ukunciphisa ukuchithwa kwe-elastin, kwaye wenze ulusu lube lukhuni kwaye lube ne-elastic.

Isicelo

Ilungele zonke iintlobo zokuchasana nemibimbi kunye nokuguga, ukulungiswa kokuqina, ukuchasana nokufota, ukunakekelwa kwe-post-natal kunye ne-post-sun body, njl. Yongezwa kwinqanaba lokugqibela lokuvelisa izimonyo.