Ishishini lobuhle belisenza konke okusemandleni ukwanelisa umnqweno wabasetyhini wokubonakala bebadala.Kwiminyaka yakutshanje, iipeptide ezishushu ezisebenzayo bezisetyenziswa kakhulu kwishishini lezithambiso.Okwangoku, ziphantse zibe ngama-50 iintlobo zemathiriyeli ephehlelelwe ngabavelisi bezinto zokuthambisa abadumileyo kumazwe aphesheya.Ngenxa yobunzima bezizathu zokuguga, iintlobo ezahlukeneyo zeepeptide zobuhle zidlala indima ekhethekileyo kwiindlela ezahlukeneyo zokufezekisa injongo yokuchasana nemibimbi.Namhlanje, makhe sijonge kwiipeptides ezahlukeneyo kunye namanani kuluhlu lwesithako.
Ulwahlulo lwemveli lwahlulahlula iipeptide zobuhle ngomatshini kwiipeptides eziSignali, iNeurotransmitter inhibiting peptides, kunye neCaried peptides.
Nye.Iimpawu zepeptide
Umqondiso we-peptides ukhuthaza ukuhlanganiswa kweprotheni ye-matrix, ngakumbi i-collagen, kwaye inokunyusa imveliso ye-elastin, i-hyaluronic acid, i-glycosaminoglycans, kunye ne-fibronectin.Ezi peptides zikhuthaza ukuhlanganiswa kwe-collagen ngokwandisa ukusebenza kweeseli ze-stromal, zenza ulusu lubukeke luthambile kwaye luselula.Ngokufana nezithako zokulwa zemveli, ezifana nevithamin C, i-vitamin A derivatives.Uphononongo olwenziwe yi-P&G lubonise ukuba i-palmitoyl pentapeptide-3 ikhuthaza ukuveliswa kwe-collagen kunye nezinye iiproteni ze-matrix ezingaphandle, kubandakanya i-elastin kunye ne-fibronectin.I-Palmitoyl oligopeptides (palmitoyl tripeptide-1) yenza into enye kakhulu, yiyo loo nto i-palmitoyl oligopeptides isetyenziswa kakhulu.I-Palmitoyl pentapeptide-3, i-palmitoyl tripeptide-1, i-palmitoyl hexapeptide, i-palmitoyl tripeptide-5, i-hexapeptide-9 kunye ne-nutmeg pentapeptide-11, ezidla ngokuthengiswa kwimarike, zizibonakaliso ze-peptides.
Mbini.Neurotransmitter peptides
Le peptide yindlela efana ne-botoxin.Ivimbela i-SNARE receptor synthesis, inqanda ukukhutshwa ngokugqithiseleyo kwe-acetycholine yesikhumba, ivimba ulwazi lwe-nerve transmission muscle contraction, kwaye ikhulula imisipha yobuso ukuze ithobe imigca emihle.Ezi peptides zisetyenziswa ngokubanzi njenge peptides zomqondiso kwaye zifaneleke ngokukodwa ukusetyenziswa kwiindawo apho izihlunu zokubonisa zigxininiswe (iikona zamehlo, ubuso, kunye nebunzi).Iimveliso ze-peptide ezimeleyo zezi: i-acetyl hexapeptide-3, i-acetyl octapeptide-1, i-pentapeptide-3, i-dipeptide ophiotoxin kunye ne-pentapeptide-3, phakathi kwayo eyona nto isetyenziswa kakhulu yi-acetyl hexapeptide-3.
Ntathu.Iipeptides ezithwalwayo
I-tripeptides (i-Gly-L-His-L-Lys (GHK)) kwi-plasma yomntu inobudlelwane obuqinileyo kunye nee-ion zethusi, ezinokuthi zenze ngokuzenzekelayo i-peptide yobhedu eyinkimbinkimbi (GHK-Cu).Isicatshulwa sobhedu siyinxalenye ebalulekileyo yokuphulukisa isilonda kunye neenkqubo ezininzi zokuphendula i-enzymatic.Uphononongo lubonise ukuba i-GHK-Cu inokukhuthaza ukukhula, ukwahlukana kunye nokuhlukana kweeseli ze-nerve kunye neeseli ezinxulumene ne-immune, kwaye inokukhuthaza ngokufanelekileyo ukuphulukiswa kwesilonda kunye nokukhula kwentsholongwane.Imveliso emelwe yipeptide yobhedu yipeptide yethusi.
Isine.ezinye iintlobo zeepeptides
Umsebenzi oqhelekileyo weepeptide zendabuko uchasene nemibimbi kunye nokuchasana nokuguga ngaphandle kwe-peptide yobhedu (i-peptide yobhedu ineempawu ezininzi ngexesha elinye).Kwiminyaka yakutshanje, iindidi ze-peptides ziye zanda, ezinye zazo ezifezekisa injongo yokuchasana nemibimbi kunye nokuchasana nokuguga kwindlela entsha kunye nembono (i-anti-free radical oxidation, i-anti-carbonylation, i-anti-inflammatory, anti -i-edema kunye nokukhuthaza ukulungiswa kwesikhumba).
1. Ulusu oluchasayo, lukhuthaza ukuqina kwesikhumba
I-Palmitoyl dipeptide-5, i-hexapeptide-8, okanye i-hexapeptide-10 iqinisa ulusu ngokuvuselela i-LamininV uhlobo lwe-IV kunye ne-VII i-collagen, ngelixa i-palmitoyl tetrapeptide-7 inciphisa ukuveliswa kwe-interleukin-6 kunye nokunciphisa ukuvuvukala.Olu hlobo lwepeptide esebenzayo luphuhliso olusebenzayo kakhulu, iimodeli ezintsha zihlala zisanda, eyona isetyenziswa kakhulu yipalm tetrapeptide-7.
2. Glycosylation
Ezi peptides zinokukhusela i-collagen ekutshatyalalisweni nasekudibaneni ngeentlobo ze-carbonyl esebenzayo (RCS), ngelixa ezinye iipeptide ezichasene ne-carbonyl zinokutshabalalisa iiradicals zasimahla.Ukhathalelo lwemveli lolusu luncamathela ukubaluleka okukhulu kwiiradicals ezichasayo, ezibonakala zichasa icarbonylation.I-Carnosine, i-tripeptide-1 kunye ne-dipeptide-4 ziipeptides ezinemisebenzi enjalo
3. Ukuphucula i-edema yamehlo, ukuphucula i-microcirculation kunye nokuqinisa ukujikeleza kwegazi
I-Acetyltetrapeptide-5 kunye ne-dipeptide-2 zi-ACE inhibitors ezinamandla eziphucula ukujikeleza kwegazi ngokuthintela ukuguqulwa kwe-angiotensin I kwi-angiotensin II.
4. Ukukhuthaza ukulungiswa kwesikhumba
I-Palmitoyl hexapeptidde-6, i-template ye-immune immune peptide, inokuvuselela ngokufanelekileyo ukwanda kwe-fibroblast kunye nokudibanisa, i-collagen synthesis kunye nokufuduka kweeseli.
Ezi peptides ezichasene nokuguga zingentla zibandakanya uninzi lwazo.Ukongeza kwi-peptides yokuguga ekhankanywe ngasentla, ezinye iipeptides ezininzi zokuzihombisa ziye zaphuhliswa kwishishini, njengokwenza mhlophe, ukuphuculwa kwebele, ukunciphisa umzimba kunye nokunye.
Ixesha lokuposa: Mar-22-2023