Umahluko kwindawo apho iityuwa ze-TFA, i-acetate, kunye ne-hydrochloride zisetyenziswa kwi-peptide synthesis.

Ngexesha le-peptide synthesis, enye ityuwa kufuneka yongezwe.Kodwa kukho iintlobo ezininzi zetyuwa, kwaye iintlobo ezahlukeneyo zetyuwa zenza iipeptide ezahlukeneyo, kwaye umphumo awufani.Ke namhlanje sikhetha ikakhulu uhlobo olufanelekileyo lwetyuwa yepeptide kwi-peptide synthesis.

1. I-Trifluoroacetate (TFA) : Le yityuwa esetyenziswa ngokuqhelekileyo kwiimveliso ze-peptide, kodwa kufuneka igwenywe kwezinye iimvavanyo ngenxa ye-biotoxicity ye-trifluoroacetate.Umzekelo, iimvavanyo zeeseli.

2. I-Acetate (AC) : I-biotoxicity ye-acetic acid incinci kakhulu kune-trifluoroacetic acid, ngoko ke i-peptides eninzi yamachiza kunye ne-cosmetic isebenzisa i-acetate, kodwa ezinye iimveliso zine-acetate engazinzanga, ngoko ukuzinza kokulandelelana kufuneka kuqwalaselwe.I-acetate yakhethwa kuvavanyo oluninzi lweeseli.

3. I-Hydrochloric acid (HCL) : Le tyuwa ayikhethwa ngokungaqhelekanga, kwaye kuphela ulandelelwano oluthile lusebenzisa i-hydrochloric acid ngeenjongo ezikhethekileyo.

4. Ityuwa ye-ammonium (NH4 +) : Le tyuwa iya kuchaphazela kakhulu ukunyibilika kunye nokuzinza kwemveliso, kufuneka ikhethwe ngokulandelelana.

5. Ityuwa yesodium (NA +) : ichaphazela ngokubanzi ukuzinza kunye nokunyibilika kwemveliso.

6. I-Pamoicacid: Le tyuwa isoloko isetyenziselwa iziyobisi ze-peptide ukwenza ii-agent ezikhutshwa ngokuqhubekayo.

7. I-CitricAcid: Le tyuwa inetyhefu encinci ye-physiological, kodwa ukulungiswa kwayo kunzima kakhulu, ngoko ke inkqubo yokuvelisa kufuneka iphuhliswe ngokulandelelana kwaye ngokwahlukileyo.

8. I-Salicylicacid: I-Salicylate inokuchaphazela ukuzinza kweemveliso ze-peptide, ngoko ke ayifane isetyenziswe.

Ezi zingentla zintlobo ezininzi zeetyuwa ze-peptide, kwaye kufuneka sikhethe ngokweempawu zeetyuwa ezahlukeneyo ekusetyenzisweni kwangempela.


Ixesha lokuposa: Jun-16-2023