I-Dna-modified i-molecule encinci esebenzayo (Indlela yokwenziwa)

Imolekyuli encinci esebenzayo i-peptide luhlobo lwe-biochemical substance phakathi kwe-amino acid kunye neprotheni, encinci kunomxholo weprotheyini, inkulu kunomxholo we-amino acid, iqhekeza leprotheni.

Iipeptides RGD, cRGD,Angiopep vascular peptide, TAT transmembrane peptide, CPP,RVG29

Iipeptides Octreotide, SP94, CTT2, CCK8, GEII

Iipeptides YIGSR, WSW,Pep-1,RVG29,MMPs,NGR,R8

"Ikhonkco le-amino acid" okanye "intambo ye-amino acid" eyenziwe yi-peptide bond edibanisa ii-amino acid ezininzi ibizwa ngokuba yi-peptide.Phakathi kwazo, iipeptides ezenziwe ngaphezu kwe-10 ukuya kwi-15 amino acids zibizwa ngokuba yi-peptides, i-peptides eyenziwe nge-2 ukuya kwi-9 amino acids ibizwa ngokuba yi-oligopeptides, kwaye i-peptides eyenziwe nge-2 ukuya kwi-15 amino acids ibizwa ngokuba yi-molecule encinci ye-peptides okanye i-peptides encinci.

I-Dna-modified i-molecule encinci esebenzayo (Indlela yokwenziwa)

Iipeptide zemolekyuli zinezi mpawu zilandelayo:

(1) I-peptides encinci ye-molecular inesakhiwo esilula kunye nomxholo omncinci, onokugqithiswa ngokukhawuleza nge-mucosa yamathumbu amancinci ngaphandle kokugaya okanye ukusetyenziswa kwamandla, kwaye ibe neempawu ze-100% zokufunxa.Ke ngoko, ukufunxwa, ukuguqulwa, kunye nokusetyenziswa kwemolekyuli encinci esebenzayo yepeptide iyasebenza kwaye iphelele.

(2) Ukungena ngokuthe ngqo kwemolekyuli encinci yeepeptide ezisebenzayo kwiiseli kuyimbonakaliso ebalulekileyo yezinto eziphilayo.Iipeptide ezincinci zemolekyuli zinokungena kwiiseli ngokuthe ngqo kwisithintelo solusu, isithintelo segazi-ingqondo, isithintelo se-placental, kunye nesithintelo se-mucosal esiswini.

(3) Iipeptide zemolekyuli ezincinci zisebenza kakhulu, kwaye ngokuqhelekileyo izixa ezincinane kakhulu zinokudlala indima enkulu.

(4) I-peptides encinci ye-molecular inemisebenzi ebalulekileyo ye-physiological, ebandakanya i-hormone, i-nerve, ukukhula kweeseli kunye nokuzala.Inokulawula ukwakheka kwenkqubo yomzimba kunye nendima ye-physiological yeeseli, kwaye igcine imisebenzi eqhelekileyo ye-physiological ye-nerve yabantu, ukugaya, ukuzala, ukukhula, ukunyakaza kwemetabolism, ukujikeleza kunye neminye imisebenzi.

(5) Iipeptide ezincinci zeemolekyuli azikwazi nje ukubonelela ngesondlo esifunekayo ekukhuleni komzimba kunye nophuhliso, kodwa zinemisebenzi ekhethekileyo yezinto eziphilayo, ezifana nokuthintela i-thrombosis, i-hyperlipidemia, i-hypertension, ukulibazisa ukuguga, ukuchasana nokukhathala, kunye nokuphucula ukugonywa komntu.