Dulaglutide, 923950-08-7

Aliasi-ulaglutide – isisombululo kwi-PBS/ dulaglutide

Inombolo yeCAS: 923950-08-7

Inombolo yeNkampani :GT-F002

Ulandelelwano: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile- Ala-Trp-Leu-Val-Lys-Gly-Gl y-Gly-OH

Ifomula yemolekyuli: C149H221N37O49

Ubunzima bemolekyuli: 3314.62

Dulaglutide CAS NO.923950-08-7.jpg

Iimpawu zobugcisa:

Imbonakalo Umgubo omhlophe
Ukucoceka (HPLC) kwaba ≥95.0%

I-heterozygosity enye yayingaphantsi kwe-2.0%

Umxholo we-Acetic acid usuka kwi-5.0% ukuya kwi-12.0%

Isiqulatho sokufuma besiyi ≤10.0%

Umxholo wepeptide wawu ≥80.0%

Ukupakisha kunye nokuThunyelwa:

Ubushushu obuphantsi, ukupakishwa kwevacuum, ngokuchanekileyo kwimilligram xa uceliwe.

Ingcaciso yeMveliso:

I-Durraglutide yi-agonist entsha esebenza ixesha elide ye-GLP-1R, ephuma kwi-fusion ye-DPP-4 inhibitory GLP-1 analogues kunye ne-immunoglobulin enzima ye-IgG4-Fc fragment.Umsebenzi wayo ufana nowokuphela kwe-GLP-1 ekubonakalisweni kweklinikhi, kunye nesiqingatha sobomi beentsuku ezi-5, kwaye inokulibazisa ngokufanelekileyo ukukhutshwa kwezintso.I-FDA ivume i-dulaglutide ukuba ifakwe i-subcutaneous injection ngoSeptemba 2014. I-European Commission ivume i-dulaglutide ye-subcutaneous injection eYurophu ngoDisemba ka-2014.

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