I-L-carnosine yi-molecule encinci ene-dipeptide yendalo e-L-shaped structure ehlala ifumaneka kwindalo kwaye iqulunqwe yi-dipeptide yendalo ye-L-shaped structures eziqhelekileyo ezifumaneka kwindalo.I-dipeptide yenziwe nge-β-alanine kunye ne-L-histidine.I-Carnosine ineendlela ezahlukeneyo ze-antioxidant yeselula, i-anti-aging kunye nemisebenzi yokhathalelo lwempilo yomzimba kunye neziphumo zonyango, ezifana noxinzelelo lwegazi, isifo senhliziyo, i-cataract ye-senile, ukubuyiswa kwezilonda, i-anti-tumor, uvavanyo lwemodeli yokuzivikela, i-anti-stress factor njalo njalo.
Indima ye
I-Carnosine yi-carnosine efunyenwe ngusosayensi waseRashiya uGulevich kunye ne-carnitine.EUnited Kingdom, Korea, Russia, kunye nezinye China, izifundo zibonise ukuba carnosine unamandla antioxidant amandla kwaye luncedo ebantwini.I-Carnosine iboniswe ukuba isuse iintlobo ze-oksijeni ezisebenzayo (i-ROS) ezenziwe ngokugqithiswa kwe-oxidation ye-fatty acids kwi-cell membrane ngexesha loxinzelelo lwe-oxidative, kunye ne-α-β unsaturated aldehydes.
Izifundo ezininzi ziye zafumanisa ukuba i-N-acetylcarnosine inesiphumo esihle kuthintelo kunye nonyango lwe-cataract.Olunye lwezi zifundo lubonise ukuba i-carnosine iphucula i-cataracts ebangelwa yi-crystalline opacities kwiigundane ezibangelwa kukutyhila kwi-guanidine.Nangona la mabango axhasa inani leenzuzo ezicingelwayo kwiso elinjengonyango lwe-carnotin ye-cataract, baye, ukuza kuthi ga ngoku, abaxhaswanga ngokupheleleyo luluntu lwezonyango oluqhelekileyo.Ngokomzekelo, iRoyal Orthopedics, yayibanga ukuba i-carnosine ayikhuselekanga kwaye ayisebenzi kunyango lwe-cataract.
Ngokutsho kwengxelo ka-2002, i-carnosine inokuphucula ubudlelwane boluntu kwaye yandise isigama esisetyenziswa ngabantwana abane-autism, kodwa ukuphuculwa okufunwayo kuphononongo kunokuvela kuphuculo, indawo ye-placebo, okanye ezinye izinto ezingabhalwanga kolu phando.
Indlela yokudibanisa
Okwangoku, iindlela zokuvelisa i-carnosine zineziphene eziqhelekileyo: ngenxa yokunciphisa ukusabela kwecala, le mpendulo yecala iqhutyelwa ngokuthatha inxaxheba kwe-L-histidine imidazole ring.I-L-histidine iya kujikeleza ubuncinane i-0.8% kwinkqubo yokuphendula, ukunciphisa imveliso yemveliso;Kwangaxeshanye, kunzima ukwahlula i-L-carnosine kunye nokucoceka okucocekileyo okucocekileyo kwimixube eyingozi (imowudi yayo yokujikeleza, imidazole isomers, njl.), echaphazela ukucoceka kwezorhwebo, kuba le mixube ineempawu ezifanayo ze-physicochemical kwi-L-carnosine.Ngenxa yobukho bale mixube, isiphumo se-L-carnosine sinobuthi, kunokuba silungiselwe ekuqaleni.
Indlela entsha yokuvelisa i-L-carnosine ngolu hlobo lulandelayo: i-phthalic anhydride iphendula i-β-alanine kunye ne-phthalic anhydride β-phthaloylalanine, i-chlorinated reagent chlorides phthaloyl-β-phthaloylalanine kwi-phthaloyl-alanine β-alanyl chloride;I-L-trialkylsilane i-compound yokukhusela iphendula kunye ne-trialkylchlorosilane okanye i-hexahydroxysilane, iphendula nge-phthalyl β-alanyl chloride condensation ye-hydrochloride, isusa iqela elikhuselayo kunye ne-alcohol e-anhydrous, kwaye idibanise i-hydrochloride kwisisombululo se-alkaline ukufumana i-intermediate hydrochlorazites hydrochlorazites kunye ne-premidiate hydrochlorazites imveliso I-L-carnosine kwi-alcohol ye-anhydrous.Le mveliso iyindandatho ye-imidazole kwi-histidine ekhuselweyo ye-L ukuphepha imiphumo emibi ye-imidazole ring kwi-L-histidine kunye nezinye izinto, kwaye ufumane i-L-carnosine ecocekileyo enemiphumo ephantsi kunye nesivuno esiphezulu kunye nomxholo.
Ixesha lokuposa: Oct-24-2023