Isishwankathelo kunye nokusetyenziswa kwe-cerulein

Isishwankathelo

I-Caerulein, ekwabizwa ngokuba yi-cerulein, yincindi yesikhumba sesele lase-Australia i-HYlacaerulea ebandakanya i-10 ye-amino acids.I-molecule ye-decapeptide enikezelwa yi-trifluoroacetate esebenza njenge-analogue ye-cholecystokinin kwiiseli ze-pancreatic vesicular kwaye inokukhokelela ekukhuselweni kwenani elikhulu le-enzymes yokugaya kunye nejusi ye-pancreatic, okubangelwa i-acute edematous pancreatitis.I-Cerutin ingasetyenziselwa ukufunda i-Nf-κb up-regulation proteins ezifana ne-intercellular adhesion molecule-1 (ICAM-1) izinto ezinxulumene nokuvuvukala ezifana ne-NADPH oxidase kunye ne-Janus kinase mediated transduction signal.Isetyenziswe ngempumelelo ukuseka iimodeli zepancreatitis ebukhali kwiimpuku, iimpuku, izinja, kunye neehamster zaseSyria (AP).Ulwelo olufakwa kwi-intravenous lulawulwa ngcono ngenaliti ye-intravenous, dermal, okanye intraperitoneal.Isetyenziswa ngokubanzi kuvavanyo lweklinikhi ye-acute edematous pancreatitis, kwaye uvavanyo lwe-in vitro lusetyenziswa kwiimodeli zeeseli.Ukongeza, isetyenziselwa ukuvavanya umsebenzi we-gallbladder.

Isishwankathelo kunye nokusetyenziswa kwe-cerulein

Ulwazi oluneenkcukacha

Ukubonakala: umgubo omhlophe

Inombolo ye-CAS: 17650-98-5

Inombolo yeGutuo : GT-F055

Ulandelelwano: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Ifomula yemolekyuli: C58H73N13O21S2

Ubunzima bemolekyuli: 1352.4

Ukunyibilika: Inyibilika kwi-50mM i-ammonium hydroxide kuxinzelelo lwe-1.0mg/ml

Isicelo

1. Isetyenziswa ngokubanzi kwimodeli ye-acute edematous pancreatitis kwizilingo zeklinikhi.

2. Isicelo kwiimodeli zeeseli kwi-vitro.

3. Isetyenziselwa uvavanyo lomsebenzi we-gallbladder.

Ukuphuhlisa imodeli yokufunda i-pancreatitis ebukhali yokufunda i-cerulein (AP) yebhayoloji yeseli, iimpawu ze-pathophysiological kunye nokubonakaliswa kwezifo eziphilayo kwi-pancreatitis ebukhali.Ukongeza kokuphanda utshintsho lwe-pulmonary yesifo se-AP, sinokubonisa ngokufanelekileyo ukusebenzisana kwe-visceral endocrine njengenqanaba le-metabolin kunye ne-CCK.Ingasetyenziselwa ukuvavanya ukubuyisela kunye nokubuyiselwa kwezicubu ezonzakeleyo emva kokupheliswa kwezinto ezinobungozi.

5. Ukusetyenziswa kweCaerulein cerulein (cerulein) kunye ne-LPS ukuseka imizekelo ye-pancreatitis inokuvelisa iziphumo ze-synergistic, yangaphambili inokuvuselela i-pancreatic enzymes ukutshabalalisa i-pancreas, kwaye ngokuqhubekayo isebenze iiseli ezivuthayo ukukhulula izinto ezivuthayo.Emva koko, i-LPS iphazamisa impendulo eqhelekileyo yabalamli abavuthayo, ngaloo ndlela iphuhlisa i-pancreatitis yendawo njengenkqubo enzima yokuvuvukala.

6. I-Cerulein ingasetyenziselwa ukukhusela intlungu ye-gallbladder, i-renal colic, kunye neentlungu ze-claudication ezingapheliyo.Ngokuqhelekileyo ithathwa ngokuba ngumchasi ongapheliyo kephalin.