I-PYY peptides i-antifungal kwaye igcina impilo ye-intestinal microbial

Xa iqela lafumanisa olu hlobo lwe-C. albicans lisebenzisa i-PYY, idatha yabonisa ukuba i-PYY yanqanda ngokufanelekileyo ukukhula kwezi bhaktiriya, ibulala iintlobo zokungunda ze-C. albicans kunye nokugcina uhlobo lwe-symbiotic yeast ye-C. albicans.

Iqela lika-Eugene Chang kwiYunivesithi yaseChicago lipapashe iphepha kwijenali yeSayensi enesihloko esithi: Peptide YY: A Paneth cell antimicrobial peptide egcina iCandida gut commensalism.

I-YY peptide (PYY) Yihomoni yamathumbu evezwa kwaye ikhuhlwe ziiseli ze-enteroendocrine (ECC) ukulawula umdla ngokuvelisa ukuhlutha.Uphononongo lwakutsha nje lufumanise ukuba i-PanethCell yamathumbu engacacanga ikwachaza uhlobo lwe-PYY, enokuthi isebenze njenge-antimicrobial peptide (AMP), ekwadlala indima ebalulekileyo ekugcineni i-intestinal microbiota isempilweni kwaye ikhusela i-Candida albicans ekubeni yi-pathogenic eyingozi. indlela.

Kuncinci okwaziwayo malunga nokulawulwa kwezi bhaktheriya nge-gut microbiome yethu.Siyazi nje ukuba iibhaktheriya zilapha phandle, kodwa asazi ukuba yintoni eyenza zibe luncedo kwimpilo yethu.Uphononongo lwakutsha nje lubonise ukuba iipeptide zeYY zibaluleke ngokwenene ekugcineni i-symbiosis yebhaktiriya yamathumbu.

Ekuqaleni, iqela lalingekakulungeli ukufunda ibhaktheriya kwi-gut microbiome.Xa uJoseph Pierre, umbhali wokuqala wephepha, wayefunda iiseli ze-intestinal endocrine ze-PYY ezivelisa iigundane, uDkt Joseph Pierre waphawula ukuba i-PYY nayo ine-Panethcells, ebalulekileyo yokukhusela i-immune kwi-mammalian gut kunye nokuthintela ukuphindaphinda kweebhaktheriya eziyingozi. ngokumetaboliza iikhompawundi ezininzi ze-bacterosuppressive.Oku akubonakali kunengqiqo kuba i-PYY ngaphambili yayicingelwa ukuba yihomoni yomdla.Xa iqela lafumanisa iindidi zeebhaktheriya, i-PYY yafunyanwa imbi ekuzibulaleni.

I-PYY peptides i-antifungal kwaye igcina impilo ye-intestinal microbial

Nangona kunjalo, xa babekhangela ezinye iintlobo zeepeptide ezifanayo ngokwesakhiwo, bafumana i-peptide efana ne-PYY-Magainin2, i-peptide ye-antimicrobial ekhoyo kwisikhumba se-Xenopus esikhusela kwi-bacterial and fungal infections.Ngoko ke, iqela lizimisele ukuvavanya iimpawu ze-PYY ze-antifungal.Ngapha koko, i-PYY ayisiyiyo kuphela i-agent esebenzayo ye-antifungal kodwa ikwayi-arhente ethile echasene ne-antifungal.

I-PYY engaguqukiyo, engaguquguqukiyo ine-36 amino acids (PYY1-36) kwaye inamandla e-peptide ye-antifungal xa iiseli ze-Paneth ziyi-metabolise emathunjini.Kodwa xa iiseli ze-endocrine zivelisa i-PYY, ihluthwa ii-amino acids ezimbini (PYY3-36) kwaye ziguqulwa zibe yihomoni yamathumbu ekwazi ukuhamba ngegazi ukuze yenze imvakalelo yokuzala exelela ingqondo ukuba awulambanga.

Candida albicans (C.albicans), ekwaziwa njenge Candida albicans, yintsholongwane ekhula ngokubanzi emlonyeni, esikhumbeni namathumbu.I-commensal emzimbeni kwimilo ye-yeast esisiseko, kodwa phantsi kweemeko ezilinganiselweyo iguqulela kwinto ebizwa ngokuba yi-fungal shape, evumela ukuba ikhule ngobuninzi, okukhokelela kwi-thrups, izifo zomlomo kunye nomqala, usulelo lobufazi, okanye ngakumbi. usulelo lwenkqubo.

Xa iqela lafumanisa olu hlobo lwe-C. albicans lisebenzisa i-PYY, idatha yabonisa ukuba i-PYY yanqanda ngokufanelekileyo ukukhula kwezi bhaktiriya, ibulala iintlobo zokungunda ze-C. albicans kunye nokugcina uhlobo lwe-symbiotic yeast ye-C. albicans.