I-Tecosactide yi-analogue yokwenziwa ye-24-peptide corticotropin.Ukulandelelana kwe-amino acid kufana ne-24 amino acids ye-amino-terminal ye-corticotropin yendalo (umntu, inkomo kunye ne-porcine), kwaye inomsebenzi ofanayo we-physiological njenge-ACTH yendalo."Kuphawulwa kukungabikho kokusabela kwe-antibody, ngokubanzi ngaphandle kweziphumo ebezingalindelekanga ezimandundu, kwaye ifaneleke ngakumbi izigulana ezichasayo okanye ezingasebenziyo kwiporcine corticotropin yendalo."
"Yenza i-adrenal hyperplasia, ivuselela ukukhutshwa kweehomoni ze-adrenocortical, ngakumbi (i-cortisol) kunye ne-mineralocorticoids efana ne-corticosterone, kwaye ivuselela ukukhutshwa kwee-androgens, kodwa ngempembelelo ebuthathaka."
Kwabakho impembelelo encinci kwi-aldosterone secretion.Isiqingatha sobomi ziiyure ezi-3.Ngo-2008, i-FDA yavuma iTecokotide evela eNovartis ukuze kufunyanwe ukungoneli kweadrenal.Okwangoku kufundwa kwiYunivesithi yaseRandboud kunyango lwe-idiopathic membranous nephropathy.
Yonke indlela yolwelo lwesigaba sokudibanisa yindlela yokudibanisa ye-ticacotide.Le ndlela inamanyathelo amaninzi, ixesha elide le-synthesis, kwaye ifuna i-catalysts ebiza kakhulu kunye nezixhobo zoxinzelelo oluphezulu, ezinobugwenxa beendleko eziphezulu, ukungcola okuninzi, ingozi yokusebenza, kunye nesivuno esiphantsi.Kuye kwaxelwa ukuba i-synthesis enye enye isebenzisa iqhinga lokukhusela i-Z, apho i-hydrogenation isetyenziselwa ukususa isiseko sokukhusela kwisinyathelo ngasinye, inamanyathelo amade, umsebenzi onzima, ixabiso eliphezulu kunye nesivuno esiphantsi.I-Serine ixhomekeke kwi-racemization ngenxa yokudibanisa enye ukuya kwelinye ngexesha lokuhlanjululwa, okunzima ukuyihlambulula.
Njengehomoni ye-adrenocorticotropic, i-ticcotide ivuselela ukukhutshwa kweehomoni ze-cortical (ingakumbi i-cortisol) kwi-adrenal cortex."Ke ngoko, akukho siphumo kwizigulane ezinokungasebenzi kakuhle kwe-adrenocortical.
I-Ticocotide yi-polypeptide yokwenziwa equkethe i-24 amino acids.Iyafana kwisakhiwo ukuya kwi-amino acids yokuqala ye-24 ye-ACTH.Ukulawulwa kwe-intravenous kwandisa ngokukhawuleza amanqanaba e-cortisol yegazi.Idriphu eqhubekayo ye-intravenous kufuneka isetyenziswe ukugcina i-cortisol concentrations yegazi.Ngenaliti ye-intramuscular, i-serum cortisol ifikelele kwincopho yayo nge-1h emva kokutofa.Emva koko, i-cortisol ephakamileyo inokugcinwa malunga neeyure ezingama-24.
Ixesha lokuposa: Jun-28-2023