intshayelelo
I-Goreratide, ekwaziwa njenge-n-acetyl-serine - aspartic acid - proline - proline -(N-Acetyl-Ser-Asp-Ls-Pro), ifinyeziwe njenge-Ac-SDKP, yi-tetrapeptide engapheliyo, i-nitrogen end acetylation, isasazwe ngokubanzi izicubu ezahlukeneyo kunye nolwelo lomzimba emzimbeni.Le tetrapeptide ikhutshwa yiprolyl oligopeptidase (POP), ebangelwa ubukhulu becala yi-thymosin eyandulelayo.Ukugxininiswa kwegazi ngokuqhelekileyo kwi-nanomole scale.
okinetics
Ngokutsho kwe-pharmacokinetic ye-Goreratide, emva kwe-injection ye-intravenous, i-Goreratide iyancipha ngokukhawuleza kunye nesiqingatha sobomi be-4 ~ 5min kuphela.I-Goreratide icocwa kwiplasma yabantu ngeendlela ezimbini:①I-Angiotensin-converting enzyme (ACE) -i-hydrolysis ekhokelwayo;②Ukuhluzwa kweGlomerular.I-hydrolysis ye-angiotensin yokuguqula i-enzyme (ACE) yindlela ephambili ye-gorelatide metabolism.
Umsebenzi webhayoloji
I-Goreratide luhlobo lwezinto ezininzi ezisebenzayo zokulawula umzimba kunye nemisebenzi eyahlukeneyo yebhayoloji.Kwaxelwa kwangaphambili ukuba i-Goreratide inokuthintela ukungena kweeseli ze-hematopoietic stem zasekuqaleni kwisigaba se-S kwaye zenze ukuba zihlale kwisigaba se-G0, zivimbela umsebenzi weeseli ze-hematopoietic stem.Emva koko kwafunyaniswa ukuba i-Goreratide inokuphucula amandla okubuyisela i-epidermal ngokukhuthaza ukubunjwa kwemithambo yegazi kunye nokukhawulezisa ukuphulukiswa kwesilonda kwiigrafti ze-epidermal ezonakalisiweyo.I-Goreratide inokuthintela ukuhlukana kweeseli ze-bone marrow stem ezikhuthazwa yi-MGM kwi-macrophages, ngaloo ndlela idlala indima echasene nokuvuvukala.I-Goreratide isanda kufunyaniswa ukuba inqanda ukwanda kweeseli ezahlukeneyo.
sebenzisa
Njengomba we-polypeptide eziphilayo, i-Goreratide inokusetyenziswa njengemathiriyeli ekrwada yeziyobisi.
Ixesha lokuposa: Apr-26-2023