Yintoni i-conotoxin?Ngaba uyakwazi ukususa imibimbi?

i-conotoxin (i-conopeptide, okanye i-CTX), i-cocktail yee-monotoxic peptides ezininzi ezikhutshelwa yimibhobho ye-toxin kunye namadlala e-Marine gastropod invertebrate Conus (Conus).Amacandelo aphambili ziikhemikhali ze-polypeptide ezisebenza ngokuthe ngqo kwiindlela ezithile ezahlukeneyo ze-calcium kunye ne-nervous system receptors.Ityhefu yenkumba nganye ineepeptide ezisebenzayo ezingama-50 ukuya kuma-200.Iindidi ezahlukeneyo ze-conic snails ziqulethe i-peptides eyahlukeneyo esebenzayo, nokuba iinkumba ezifanayo ze-conic ngenxa yemimandla eyahlukeneyo, iinxalenye zazo ze-toxin zinokwahluka, ngokusisiseko kunokubakho ngaphezu kwe-50 yamawaka eepeptide ezahlukeneyo ezisebenzayo kwi-conic snail poison.I-Conotoxin ubukhulu becala yenziwe ngeentsalela eziyi-10 ~ 40, eziqulathe amaqela amabini okanye amathathu e-disulfide bond, ifunyaniswa njengelona nani lincinci le-nucleic acid ye-biological neurotoxic peptide, ikwayeyona ingxinano inkulu ye-disulfide bond encinci peptide, inokufakwa kuzo zonke iintlobo. iziteshi ze-calcium kunye neentlobo ze-receptor kunye ne-subtypes.

Iziphumo ze-conotoxin ekushwabaneni kwesikhumba zilandelayo:

I-Conotoxin, yintsapho ye-conotoxin, luhlobo lwesiphumo esongezelelweyo sokuguga kwecala, oku kungenxa yokuba inokunciphisa ubuso bolusu imigca emihle, ikhulule ukuqina kolusu, ibe lula kwaye ilula, iphele imigca emihle, emva koko ifumane wonke umntu. intandokazi.Ibizwa ngokuba “yiNkwenkwezi eNqanda ukuguga.”

I-Conotoxin inokuthintela ukuveliswa kwemigca emihle yobuso, iphucule ukukhululeka kolusu, iphucule ukunwebeka kolusu, iphucule umgangatho wolusu kunye nobunzulu bomgca ocolekileyo.Inceda ekunciphiseni ukudumba kolusu, ivumela ulusu ukuba lulungise ukunwebeka kwalo kwaye luphucule umgangatho wolusu.

I-Conotoxin iye yaba yenye yezona ndlela zixhaphakileyo zokulwa nokuguga ngenxa yokusebenza kwayo kakuhle ekuchaseni ukuguga.Ngobuchule obukhethekileyo, i-conotoxin inokufakwa eluswini lobuso ukuphucula ukuqina kwayo.

I-Conotoxin njengohlobo lwe-agent echasene nokuguga, inefuthe elinamandla lokuchasa ukuguga, ngoko inokuzuza kakhulu ukuphucula imeko yolusu, ukususa imibimbi, ukwenza ulusu lubukeke lulutsha luhle ngakumbi.