Namhlanje, ukutyeba ngokugqithiseleyo kuye kwaba ngubhubhani wehlabathi lonke, kwaye iziganeko zokutyeba ziye zanda kumazwe ehlabathi jikelele.Ngokutsho kweWorld Health Organization, kuqikelelwa ukuba i-13 ekhulwini labantu abadala ehlabathini batyebe ngokugqithiseleyo.Okubaluleke ngakumbi, ukutyeba kakhulu kunokukhokelela kwisifo se-metabolic syndrome, esikhatshwa ziingxaki ezahlukeneyo ezifana nohlobo lwe-2 yesifo seswekile, uxinzelelo lwegazi, i-nonalcoholic steatohepatitis (NASH), isifo sentliziyo, kunye nomhlaza.
NgoJuni 2021, i-FDA yavuma i-Semaglutide, ichiza lokunciphisa umzimba eliphuhliswe nguNovo Nordisk, njenge-Wegovy.Ndiyabulela kwiziphumo zayo ezibalaseleyo zokulahleka kwesisindo, iprofayile yokhuseleko elungileyo kunye nokutyhala abantu abadumileyo abanjengoMusk, iSemaglutide iye yathandwa kakhulu kwihlabathi liphela kangangokuba kunzima ukuyifumana.Ngokwengxelo yezemali kaNovo Nordisk ka-2022, iSemaglutide ivelise intengiso ukuya kuthi ga kwi-12 yeebhiliyoni zeedola ngo-2022.
Kungekudala, uphando olupapashwe kwi-Journal lubonise ukuba i-Semaglutide nayo inenzuzo engalindelekanga: ukubuyisela umbulali wendalo (NK) umsebenzi weseli emzimbeni, kubandakanywa nokukwazi ukubulala iiseli zomhlaza, ezingaxhomekekanga kwimiphumo yokulahlekelwa kwesisindo somzimba.Olu pho nonongo luneendaba ezilungileyo kakhulu kwizigulane ezityebileyo ezisebenzisa i-Semaglutide, ezibonisa ukuba iyeza lineenzuzo eziphambili zokunciphisa ingozi yomhlaza ngaphezu kokulahlekelwa kwesisindo.Isizukulwana esitsha samachiza, esimelelwe nguSemaglutide, siguqula unyango lokukhuluphala kwaye siye samangalisa abaphandi ngemiphumo yayo enamandla.
Ke, ngubani onokufumana ukwehla kwesisindo esihle kuyo?
Okokuqala, iqela lahlulahlula abantu abatyebe kakhulu baba ngamaqela amane: abo kufuneka batye ngakumbi ukuze bazive behluthi (ukulamba kwengqondo), abo batya kubunzima obuqhelekileyo kodwa baziva belambile kamva (indlala yamathumbu), abo batya ukuze bamelane nayo. iimvakalelo (ukulamba ngokweemvakalelo), kunye nabo banemetabolism ecothayo ngokwentelekiso (iimetabolists ezicothayo).Iqela lafumanisa ukuba izigulana ezilambileyo ezityebileyo zisabela kakuhle kula machiza amatsha elahleko ngenxa yezizathu ezingaziwayo, kodwa abaphandi baqiqa ngelithi kungenxa yokuba amanqanaba e-GLP-1 ayengekho phezulu, yiyo loo nto beye batyeba kwaye, ngenxa yoko, ubunzima obungcono. ilahleko kunye ne-GLP-1 receptor agonists.
Ukukhuluphala ngoku kuthathwa njengesifo esingapheliyo, ngoko ke la mayeza acetyiswa ukuba athathe unyango lwexesha elide.Kodwa ixesha elide kangakanani?Akucaci, kwaye lo ngumkhombandlela oza kuphononongwa ngokulandelayo.
Ukongezelela, la mayeza amatsha okunciphisa umzimba ayesebenza kakhulu kangangokuba abanye abaphandi baqala ukuxoxa malunga nokuba ungakanani ubunzima obulahlekileyo.Ukunciphisa umzimba akugcini nje ukunciphisa amanqatha kodwa kukhokelela ekulahlekeni kwemisipha, kwaye ukuchithwa kwemisipha kwandisa umngcipheko wesifo senhliziyo, i-osteoporosis, kunye nezinye iimeko, ezixhalabisa ngokukhethekileyo abantu abadala kunye nabanesifo senhliziyo.Aba bantu bachaphazelekayo yinto ebizwa ngokuba yi-obesity fallacy - ukuba ukulahleka kwesisindo kuhambelana nokufa okuphezulu.
Ke ngoko, amaqela aliqela sele eqalisile ukuphonononga iziphumo zedosi ephantsi yokusebenzisa la mayeza anoveli okunciphisa ubunzima ukujongana neengxaki ezinxulumene nokutyeba, ezifana ne-apnea, isifo sesibindi esinamafutha, kunye nohlobo lwe-2 yeswekile, engafuneki ukuncipha kobunzima.
Ixesha lokuposa: Oct-23-2023