Transdermal Peptide/888486-23-5/GT Peptide/Peptide Supplier

Inkcazo 

Transdermal PeptideI-Disulfide (TD 1 Disulfide(peptide)) yi-11-amino acid polypeptide ebophelela kwi-Na +/K+-ATPase beta-subunit (ATP1B1).Isebenzisana kakhulu neC terminus ye-ATP1B1.Transdermal PeptideI-Disulfide iyakwazi ukunyusa ukuhanjiswa kwamanye ama-macromolecules esikhumbeni.Ubukho be-transdermal peptide disulfide, iseli ilawula izinga le-ATP1B1 ukugcina umsebenzi wayo kunye nesakhiwo ngenxa yokubopha okuthe ngqo kwe-transdermal peptide disulfide kwi-ATP1B1.Ngenxa yoko, intetho ye-ATP1B1 yonyuswa.Nangona kunjalo, ekuhambeni kwexesha, ezinye iimolekyuli ze-transdermal disulfide peptide zinokuhanjiswa kwiseli nge-endocytosis;Ngenxa yoko, intetho ye-ATP1B1 iye yancitshiswa.Ukusebenzisana phakathi kwe-transdermal peptide disulfide kunye ne-ATP1B1 ayitshintshi kuphela inkcazo ye-ATP1B1, kodwa iphinde itshintshe indawo ye-ATP1B1, kwaye emva koko itshintshe isakhiwo se-epidermal layer.Olu nxibelelwano lunokuthotywa zii-inhibitors okanye abakhuphisana nabo, okukhokelela ekunciphiseni ukuhanjiswa kweziyobisi ze-macromolecular kulo lonke ulusu.

Iinkcukacha

Imbonakalo: Imhlophe ukuya kumgubo omhlophe

Ubunyulu(HPLC):≥98.0%

Ukungacoceki okukodwa:≤2.0%

Umxholo we-Acetate(HPLC): 5.0%～12.0%

Isiqulatho samanzi (uKarl Fischer):≤10.0%

Umxholo wePeptide:≥80.0%

Ukupakisha kunye nokuThumela: Ukushisa okuphantsi, ukupakisha i-vacuum, ngokuchanekileyo kwi-mg njengoko kufuneka.

Ungaodola Njani?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Oda kwi-intanethi.Nceda ugcwalise ifom ye-odolo ye-intanethi.

3. Nika igama le-peptide, inombolo ye-CAS okanye ulandelelwano, ukucoceka kunye nokuguqulwa ukuba kuyimfuneko, ubungakanani, njl.njl. siya kubonelela ngekowuteshini kwiiyure ezi-2.

4. Umyalelo wokuthotyelwa kwemvumelwano yokuthengisa esayiniweyo ngokufanelekileyo kunye ne-NDA (isivumelwano esingaveziyo) okanye isivumelwano esiyimfihlo.

5. Siya kuqhubeka sihlaziya inkqubo ye-odolo ngexesha.

6. Ukuhanjiswa kwePeptide yi-DHL, Fedex okanye abanye, kunye ne-HPLC, MS, COA iya kubonelelwa kunye nomthwalo.

7. Umgaqo-nkqubo wembuyekezo uya kulandelwa ukuba kukho ukungangqinelani komgangatho okanye inkonzo yethu.

8. Inkonzo emva kokuthengisa: Ukuba abathengi bethu banemibuzo malunga nepeptide yethu ngexesha lovavanyo, nceda uzive ukhululekile ukuqhagamshelana nathi kwaye siya kuyiphendula ngexesha elifutshane.

Zonke iimveliso zenkampani zisetyenziselwa kuphela injongo yophando lwesayensi, yona'Ithintelwe ukuba isetyenziswe ngokuthe ngqo nguye nawuphi na umntu emzimbeni womntu.

FAQ:

Ngaba iipeptides ezineCys zancitshiswa ngaphambi kokuthunyelwa?

Ukuba i-peptide ayifunyaniswanga ukuba i-oxidized, ngokuqhelekileyo asiyinciphisi i-Cys.Zonke iipolypeptides zifumaneka kwiimveliso ezikrwada ezihlanjululweyo kunye ne-lyophilized phantsi kweemeko ze-pH2, ezithi okungenani zithintele i-oxidation yeCys.Iipeptide eziqulethe iiCys zicocwa kwi-pH2 ngaphandle kokuba kukho isizathu esicacileyo sokuhlanjululwa kwi-pH6.8.Ukuba ukucocwa kwenziwa kwi-pH6.8, imveliso ehlambulukileyo kufuneka iphathwe nge-asidi ngokukhawuleza ukukhusela i-oxidation.Kwinqanaba lokugqibela lokulawula umgangatho, kwiipeptides eziqulethe i-Cys, ukuba ubukho be-molecular weight (2P + H) into ifunyenwe kwimephu ye-MS, ibonisa ukuba i-dimer yenziwe.Ukuba akukho ngxaki nge-MS kunye ne-HPLC, siya ku- lyophilize ngokuthe ngqo kwaye sithumele iimpahla ngaphandle kokuqhubela phambili.Kufuneka kuqatshelwe ukuba iipeptide eziqulathe iiCys zingena kwi-oxidation ecothayo ngokuhamba kwexesha, kwaye inqanaba le-oxidation lixhomekeke kulandelelwano lwepeptide kunye neemeko zokugcina.

Ufumanisa njani ukuba i-peptide ilotshiwe?

Sisebenzisa impendulo ka-Ellman ukuvavanya ukuba ukubunjwa kweringi kugqityiwe.Ukuba uvavanyo lukaEllman luthi positive (yellow), ukusabela kweringi akuphelelanga.Ukuba iziphumo zovavanyo zithi negative (hayi tyheli), ukusabela kweringi kugqityiwe.Asiboneleli ngengxelo yohlalutyo lokuchongwa kwebhayisikile kubathengi bethu.Ngokuqhelekileyo, kuya kubakho inkcazo yeziphumo zovavanyo luka-Ellman kwingxelo ye-QC.

Ndifuna i-cyclic peptide, equlethe i-tryptophan, ingaba iya kuba yi-oxidized?

I-oxidation ye-tryptophan yinto eqhelekileyo kwi-peptide oxidation, kwaye iipeptides zihlala zihamba ngebhayisikile ngaphambi kokucocwa.Ukuba i-oxidation ye-tryptophan iyenzeka, ixesha lokugcinwa kwepeptide kwikholamu ye-HPLC iya kutshintsha, kwaye i-oxidation inokususwa ngokucoca.Ngaphaya koko, iipeptides ezineoksijini nazo zinokubonwa nguMS.

Ngaba kuyimfuneko ukubeka isithuba phakathi kwepeptide kunye nedayi?

Ukuba uza kuncamathelisa imolekyuli enkulu (efana nedayi) kwipeptide, kungcono ukubeka isithuba phakathi kwe peptide kunye ne ligand ukunciphisa ukuphazamisana ne receptor ngokusonga i peptide ngokwayo okanye ngokusonga ukudibanisa kwayo.Abanye abafuni zikhefu.Ngokomzekelo, ekugoqweni kweeprotheni, kunokwenzeka ukugqiba ukuba kude kangakanani ukuhlukana kwesakhiwo se-amino acid ngokufaka idayi ye-fluorescent kwindawo ethile.

Ukuba ufuna ukwenza i-biotin modification kwi-terminal ye-N, ngaba kufuneka ubeke isithuba phakathi kwe-biotin kunye nolandelelwano lwepeptide?

Inkqubo eqhelekileyo yokubhala i-biotin esetyenziswa yinkampani yethu kukuncamathisela i-Ahx kwikhonkco le-peptide, ilandelwe yi-biotin.I-Ahx yi-6-carbon compound esebenza njengomqobo phakathi kwe-peptide kunye ne-biotin.

Ngaba unokunika iingcebiso malunga noyilo lweepeptide zephosphorylated?

Njengoko ubude bukhula, ukusebenza kakuhle kokubopha ngokuthe ngcembe kuncipha ukusuka kwi-amino acid ye-phosphorylated ukuya phambili.Indlela yokudibanisa isuka kwi-C terminal ukuya kwi-N terminal.Kunconywa ukuba iintsalela emva kwe-amino acid ye-phosphorylated akufanele idlule i-10, oko kukuthi, inani leentsalela ze-amino acid ngaphambi kokuba i-amino acid ye-phosphorylated ukusuka kwi-N terminal ukuya kwi-C terminal ayifanele idlule i-10.

Kutheni i-n-terminal acetylation kunye ne-C-terminal amidation?

Olu hlengahlengiso luthintela i-peptide ekuthotyweni kwaye ivumela i-peptide ukuba ilinganise isimo sayo sokuqala samaqela e-alpha amino kunye ne-carboxyl kwiprotheni engumzali.