IsiNgesi: Omiganan
IsiNgesi: Omiganan
Inombolo ye-CAS: 204248-78-2
Ifomula yemolekyuli: C₉₀H₁₂₇N₂₇O₁₂
Ubunzima bemolekyuli: 1779.15
Ulandelelwano: ILRWPWWPWRRK-NH2
Ukubonakala: umgubo omhlophe okanye omhlophe omhlophe
Isebenza njani iOmiganan:
Yipeptide encinci kakhulu kwaye ke ngoko kunzima ukuyichonga kunye neleyibheli yeproteolysis;Ifakwe kwi-C terminus ukuqhubeka nokuchasa iproteolysis kunye nokususa umrhumo ongalunganga weqela le-carboxyl.I-amphiphilic kwaye inokusebenzisana ngamandla kunye ne-membrane yeseli.Kulindeleke ukuba inwebu yeseli ibe yenye yeethagethi zabo eziphambili.Yipolycation ethanda ukusebenzisana kwabo kunye ne-membrane yebhaktiriya ehlawuliswa kakubi kunye nomphandle we-zomeric wangaphandle we-lipopolysaccharide (LPS) kunye ne-mammalian membranes kune-peptidoglycan.Kwibhaktheriya, i-membrane enokubakho iyingozi ngakumbi kuneeseli ezanyisayo, ezinokuthi ziphucule ukubophelela kwe-antibiotic kunye nokudluliselwa.Into yokugqibela sisiphene seklinikhi yokuba i-antiinflammatory cytidine nayo inomsebenzi kwi-erythrocytes, ngelixa i-Omiganan ibonakala ingaphantsi kwe-hemolytic.Njengoko kukhankanyiwe ngasentla, iintsalela ezihlawulisiweyo ze-omiga-nan zifumaneka kufuphi ne-terminal nganye, kude nommandla ophakathi we-hydrophobic we-peptide, kwaye intlawulo epheleleyo ye-peptide inyuka ukusuka kwi-4 + ukuya kwi-5+, enokuchazwa ngokunciphisa i-hemolysis. , kuba olu tshintsho lungazithandi izinto ezifana ne-peptide ezinxulumene ne-zwitt-rionic mammalian membranes.Oku kuqinisekiswa ziziphumo ze-Staubitz kunye nabanye, apho i-fragment ephakathi ye-cetin egciniweyo ye-anti-inflammatory kwi-omiganan inxulunyaniswa nomsebenzi, ngelixa i-terminal fragment ibonakala ilungisa ukuchaneka kwethagethi.
I-Omiganan isetyenziselwa:
I-Omiganan yinoveli ye-synthetic cationic antimicrobial peptide okwangoku ephantsi kophuhliso lokuthintela usulelo olunxulumene ne-catheter kunye nonyango lwe-acne kunye ne-rosacea.Kolu phononongo, sivavanye ukusebenza kokusetyenziswa kwejeli ye-omiganan kwimifuziselo emibini yokufakelwa kwesikhumba (kwisikhumba sehagu ye-vivo kunye nesikhumba sehagu ye-vivo).I-omiganan0 yavavanywa kwimodeli ye-ex vivo ye-porcine ye-colonization yesikhumba 1 ukuya kwi-2% ye-agent ye-gel ibonise umphumo onamandla oxhomekeke kwi-dose ngokuchasene ne-Gram-positive kunye ne-Gram-negative bacteria kunye ne-yeast, kunye neziphumo eziphezulu ezibonwayo phakathi kwe-1 kunye ne-2%.Kwakungekho mmahluko obalulekileyo kumsebenzi phakathi kwe-methicillin-resistant and susceptible Staphylococcus aureus, kwaye umsebenzi weziyobisi awuzange uchaphazeleke ngobukhulu bento egotyiweyo.I-Omiganan1% i-gel inomsebenzi okhawulezayo we-antimicrobial, kunye ne-2.7log (10) yokunciphisa iiyunithi ze-colon-forming ye-Staphylococcus epidermolis / indawo kwi-1 h kunye ne-5.2log (10) yokunciphisa i-flagella / indawo kwi-24 h emva kokusetyenziswa.Umsebenzi onamandla we-antibacterial kunye ne-antifungal ye-Omiganan1% ijeli yaqinisekiswa zezinye izifundo kwimodeli ye-dolphin yekholoni yesikhumba.Isishwankathelo, ii-gels ze-Omiganem zibonakaliswe ukuba zineempembelelo ezikhawulezayo ze-bactericidal kunye ne-bactericidal kunye nefuthe elicacileyo elixhomekeke kwi-dose kwi-spectrum ebanzi yezinto ezisulelayo.Ezi ziphumo zibonisa ngakumbi amandla echiza njenge-agent ye-antimicrobial.
Ixesha lokuposa: Jun-27-2023