Ezi peptide ze-antimicrobial ekuqaleni zazisuka kwiinkqubo zokukhusela izinambuzane, izilwanyana ezincancisayo, izilwanyana ezihlala emanzini, njl. njl., kwaye ikakhulu ziquka iindidi ezine:
1. I-cecropin yayikhona ekuqaleni kwi-immune lymph lymph ye-Cecropiamoth, efumaneka kakhulu kwezinye izinambuzane, kunye ne-peptides ye-bactericidal efanayo nayo ifumaneka kumathumbu ehagu.Ngokuqhelekileyo zibonakaliswa ngummandla we-alkaline ye-N-terminal elandelwa yiqhekeza elide le-hydrophobic.
2. I-Xenopus antimicrobial peptides (magainin) iphuma kwimisipha kunye nesisu samasele.Isakhiwo se-xenopus antimicrobial peptides nayo yafunyanwa i-helical, ngakumbi kwiindawo ze-hydrophobic.Ukucwangciswa kwe-xenopus antipeptides kumaleko e-lipid kwafundwa yi-N-ebhalwe ngu-N-igama eliqinileyo lesigaba se-NMR.Ngokusekwe kutshintsho lwekhemikhali ye-acylamine resonance, iihelikhi ze-xenopus antipeptides zaziyimiphezulu ye-bilayer enxuseneyo, kwaye zinokuhlangana zenze ikheji eyi-13mm enesakhiwo se-helical samaxesha athile esiyi-30mm.
3. idefensin Defensin peptides zithathwe kwi polykaryotic neutrophil rabbit polymacrophages kunye ne-nuclear lobule epheleleyo kunye neeseli zamathumbu ezilwanyana.Iqela leepeptides ezilwa neentsholongwane ezifana neepeptide zokukhusela i-mammalian zakhutshwa kwizinambuzane, ezibizwa ngokuba "ziipeptide zokukhusela izinambuzane".Ngokungafaniyo neepeptide zokhuselo lwe-mammalian, iipeptide zokhuselo lwezinambuzane zisebenza kuphela ngokuchasene neebhaktheriya ezineGram.Nkqu iipeptide zokukhusela inambuzane ziqulethe iintsalela zeCys ezintandathu, kodwa indlela yokudibanisa i-disulfide enye kwenye yahlukile.Indlela yokubopha ibhulorho ye-intramolecular disulfide ye-antibacterial peptides ekhutshwe kwi-Drosophila melanogast yayifana naleyo yeepeptide zokukhusela izityalo.Ngaphantsi kweemeko zekristale, iipeptide zokukhusela zibonakaliswa njenge-dimers.
4.I-Tachyplesin ithathwe kwi-horseshoe crabs, ebizwa ngokuba yi-horseshoecrab.Uphononongo loqwalaselo lubonisa ukuba lwamkela i-antiparallel B-ukusonga uqwalaselo (3-8 izithuba, 11-16 izikhundla), aphoβ-i-angle ixhunyiwe komnye nomnye (izikhundla ze-8-11), kwaye iibhondi ezimbini ze-disulfide zenziwe phakathi kwe-7 kunye ne-12 izikhundla, kwaye phakathi kwe-3 kunye ne-16 izikhundla.Kulo lwakhiwo, i-hydrophobic amino acid ibekwe kwicala elinye lendiza, kwaye iintsalela ze-cationic ezithandathu zivela kumsila we-molecule, ngoko ke isakhiwo sibuye sibe yi-biophilic.
Oku kulandela ukuba phantse zonke iipeptide ze-antimicrobial ziyi-cationic kwindalo, nangona zihluka ngobude kunye nokuphakama;Kwinqanaba eliphezulu, nokuba kukwimo ye-alpha-helical okanyeβ-ukusonga, ulwakhiwo lwe-bitropic luphawu oluqhelekileyo.
Ixesha lokuposa: Apr-20-2023