Indlela yokusebenza
Ii-Enzymes ziiproteni ezibangela ukusabela kweekhemikhali.I-enzyme isebenzisana ne-substrate ukuyiguqula ibe yimveliso yokugqibela.Ii-inhibitors zibophelela omnye komnye ukukhusela i-substrate ekungeneni kwindawo esebenzayo ye-enzyme kunye / okanye ukukhusela i-enzyme ekuqhubeni ukusabela.Kukho iintlobo ezininzi zee-inhibitors ezibandakanya: ezingezizo ngqo, ezingenakuguqulwa, ezibuyiselwa umva - ezikhuphisanayo kwaye azikhuphisani.I-reversible inhibitors ibophelela kwi-enzymes kunye ne-non-covalent interactions (umzekelo, ukusebenzisana kwe-hydrophobic, i-hydrogen kunye ne-ionic bonds).Amanyathelo olawulo angacaciswanga abandakanya ekugqibeleni denatuation inxalenye yeprotein ye-enzyme kwaye ngaloo ndlela kuthintelwe zonke iintshukumo zomzimba okanye zekhemikhali.Ii-inhibitors ezithile zisebenza kwi-enzyme enye.Uninzi lwetyhefu lusebenza ngokwee-enzymes zolawulo oluthile.Iinhibitors ezikhuphisanayo zizo zonke iikhompawundi eziphantse zifane nesakhiwo sekhemikhali kunye nejometri yemolekyuli ye-reaction substrate.I-inhibitor inokusebenzisana ne-enzyme kwindawo esebenzayo, kodwa akukho mpendulo eyenzekayo.I-Noncompetitive inhibitors zizinto ezisebenzisana nee-enzymes kodwa ubukhulu becala azidibanisi kwindawo esebenzayo.Injongo yenetha ye-inhibitor engakhuphisananga kukutshintsha ukuma kwe-enzyme, ngaloo ndlela ichaphazela indawo esebenzayo, ukuze i-substrate ingakwazi ukusebenzisana ne-enzyme ukuze iphendule.Ii-non-competitive inhibitors ziyakwazi ukuguqulwa.I-Irreversible inhibitors zenza i-covalent bonds eyomeleleyo kunye ne-enzymes.Ezinye zezi zithinteli zinokusebenza okanye zijikeleze indawo esebenzayo.
sebenzisa
Ii-Enzymes zisetyenziswa ngokubanzi kurhwebo kwiindawo zoshishino, ezifana nokuhlamba izitya, ukutya kunye namashishini okutywala.Iiproteases zisetyenziswa kwi-"microbial" yokuhlamba umgubo ukukhawulezisa ukuqhekeka kweeprotheyini kubumdaka obufana negazi kunye namaqanda.Ukusetyenziswa ngokurhweba kwee-enzymes kubandakanya ukuba zinyibilike emanzini, nto leyo eyenza kube nzima ukuphinda isetyenziswe, kwaye ezinye iimveliso zokuphela zithintela umsebenzi we-enzyme (ulawulo lwempendulo).
Iimolekyuli zamachiza, iimolekyuli ezininzi zamachiza ngokusisiseko zizithinteli ze-enzyme, kwaye i-drug enzyme inhibitors zihlala ziphawulwa ngobuchule bazo kunye nesiphumo.Ukuchaneka okuphezulu kunye nesiphumo sibonise ukuba amachiza aneziphumo ezibi ezisezantsi kunye netyhefu ephantsi.I-enzyme inhibitors ifumaneka kwindalo kwaye icwangciswe kwaye iveliswe njengenxalenye encinci ye-pharmacology kunye ne-biochemistry 6.
Iityhefu zendalo ubukhulu becala zii-enzyme inhibitors eziye zavela ukuze zikhusele imithi okanye izilwanyana ezahlukeneyo kumarhamncwa.Ezi tyhefu zendalo ziquka uninzi lweyona khompawundi ziyityhefu ezakhe zafunyanwa.
Ixesha lokuposa: Apr-25-2023