I-Palmitoyl pentapeptide-4 inokuphucula ulusu lobuso olugugayo

I-Palmitoyl pentapeptide-4 idla ngokusetyenziswa njengejeli yesiseko kwiimveliso zokukhathalela ulusu ezichasa imibimbi.

I-Palmitoyl pentapeptide-4 (pre-2006 palmitoyl pentapeptide-3) isetyenziswa ngokuqhelekileyo njengejeli yesiseko kwiimveliso zokunakekelwa kwesikhumba ezichasene nemibimbi.NgokwaseSpain ukhathalelo lwesikhumba olusebenzayo lomenzi wezithako ngo-2000 njengeshishini labo lokhathalelo njengesithako esisebenzayo, i-palmitoyl pentapeptide-4 luchungechunge lwe-peptide yokusetyenziswa kwangoko kunye neyona polypeptide isetyenziswa kakhulu, iimveliso zasekhaya nezangaphandle zisetyenziswa kakhulu njenge. isithako esisebenzayo ekukhathaleni ulusu oluchasene nemibimbi, kwiimveliso ezininzi zokhathalelo lwesikhumba ezichasene nemibimbi zihlala zivela kumzobo wayo.Ngokunyusa i-collagen ngokusebenzisa i-dermis, inokuguqula inkqubo yokuguga ngokwakha kwakhona ulusu ngaphakathi ngaphakathi.Ichaphazela i-collagen, i-elastic fibers kunye ne-hyaluronic acid yanda, yandisa ukufuma kwesikhumba kunye nokugcinwa komswakama, ukwandisa ubukhulu bolusu kunye nokunciphisa imigca emihle.

I-Palitoyl pentapeptide-4 (i-Pal-lys-thr-Lys-ser = i-Pal-KTTKS) iqulethe i-amino acids ezintlanu ezidityaniswe ne-16-carbon aliphatic chain ukunyusa ukunyanzeliswa kwe-molecule ngokusebenzisa isakhiwo se-lipid kwesikhumba.Le imajarini.I-Palmitoyl pentapeptide-4 yi-peptide yesithunywa elawula ukusebenza kweseli ngokusebenzisana ne-receptors ethile.Baye bavula iijini ezibandakanyekayo ekuphuculeni i-matrix engaphandle kunye nokwanda kweeseli.I-Palmitoyl pentapeptide-4 ine-anti-wrinkle kunye ne-skin-tightening effect ngokuvula i-synthesis entsha ye-macromolecules kwi-matrix ye-extracellular.

Indlela yokusebenza

Izifundo ze-in vitro zifumene i-212% yokunyuka kohlobo lwe-collagen synthesis, i-100% ukuya kwi-327% yokwanda kwe-IV ye-collagen synthesis, kunye ne-267% yokwanda kwe-hyaluronic acid synthesis.I-Collagen I ifumaneka kuluhlu olubanzi lweefom ze-19 ze-collagen emzimbeni.Ke ngoko, ukonyusa imveliso epheleleyo ye-collagen I inefuthe elibalulekileyo ekwakhiweni kwakhona kwesikhumba.Uphononongo lweenyanga ezintandathu kwi-vivo lufumene ukuncipha komndilili we-17 pesenti kubunzulu bemigca ecolekileyo, i-68 pesenti kwindawo yemigca ecolekileyo enzulu, i-51 pesenti kwindawo yemigca ecolekileyo ephakathi, kunye ne-16 ekhulwini kuburhabaxa bemigca. ulusu.