I-Glucagon-like peptide 1 receptor (GLP-1R) i-agonists ifunyenwe ukunciphisa ukusetyenziswa kotywala kwiimpuku kunye nabantu abatyebileyo abanengxaki yokusetyenziswa kotywala (AUD).Nangona kunjalo, iidosi eziphantsi ze-semaglutide (semaglutide), inhibitor enamandla ye-GLP-1, ibonakaliswe ukunciphisa ukusetyenziswa kotywala kwiintonga kunye nabantu abagqithisileyo abane-AUD.Amathuba okuba i-agonist enamandla aphezulu kunye nobudlelwane be-GLP-1R) ithobe iimpendulo ezinxulumene notywala kwiimpuku, kunye neendlela ezisisiseko ze-neurological, ayaziwa.
I-Somallutide, iyeza elisetyenziswa ngoku kunyango lwe-2 yeswekile kunye nokutyeba, inokuba lunyango olusebenzayo lokuxhomekeka etywaleni.kuphononongo olupapashwe kwiphephancwadi yamazwe ngamazwe i-eBioMedicine enesihloko esithi "I-Semaglutide iyanciphisa ukuThuthwa koTywala kunye nokuBuyiselwa kwakhona okufana nokusela kwiiRats zamadoda nabasetyhini," izazinzulu ezivela kwiYunivesithi yaseGothenburg kunye namanye amaziko ziye zafumanisa ukuba i-somallutide inokunciphisa ukubuyiswa kotywala kunye nokusela utywala kwiigundane. ngaphezulu kwesiqingatha.
Imfuno ye-somallutide, ethengiswa phantsi kwamagama e-brand efana ne-Ozempic (semaglutide), iye yanda ukususela ekubeni iyeza livunyiwe ukunyangwa kokukhuluphala, okuye kwabangela ukuba kube nzima kakhulu ukuyifumana;Kukwakho neengxelo ezithetha ngabantu abatyebe kakhulu okanye abanesifo seswekile besithi umnqweno wabo wokusebenzisa utywala wehla emva kokuba beqalise ukusebenzisa eli chiza.Kule mihla, abantu abaxhomekeke etywaleni baphathwa ngendibaniselwano yeendlela zengqondo kunye neziyobisi.Ngoku kukho amachiza amane avunyiweyo.Ekubeni ukuxhomekeka kotywala sisifo esinezizathu ezininzi kunye nokusebenza okungafaniyo kwala machiza, ukuphuhliswa kweendlela zonyango kubaluleke kakhulu.
I-Somallutide lichiza elisebenzisa ixesha elide ukuba izigulane kufuneka zilithathe kanye ngeveki, kwaye lichiza lokuqala elisebenza kwi-GLP-1 receptor elinokuthi lithathwe njengethebhulethi.Kuphononongo, abaphandi banyange iimpuku ezixhomekeke etywaleni nge-somalutide, eyanciphisa kakhulu utywala beempuku kwaye yanciphisa ukusela okuhambelana nokuphinda, ingxaki enkulu kubantu abaxhomekeke etywaleni kuba abantu baphinda babuyele emva kwexesha lokuzila kwaye basebenzise utywala obuninzi. kunokuba babesenza ngaphambi kokuba baziyeke.Iigundane eziphathwayo zakwazi ukunciphisa utywala ngesiqingatha xa kuthelekiswa neempuku ezingaphendulwanga, abaphandi bathi.Ukufunyaniswa okunomdla kuphononongo yayikukuba i-somallutide yanciphisa ukuselwa kotywala ngokulinganayo kwiigundane zamadoda nabasetyhini.
Uphononongo luphinde lwachaza umphumo omuhle ngokumangalisayo, nangona izifundo zeklinikhi ze-somallutide zisekude ngaphambi kokuba zisetyenziswe ukunyanga ukuxhomekeka kotywala;Ukuqhubela phambili, ichiza linokuba luncedo kakhulu kubantu abatyebileyo kunye nokuxhomekeka kotywala, kwaye abaphandi bathi iziphumo zinokuthwala ebantwini, njengoko ezinye izifundo zeziyobisi ezixhomekeke etywaleni zisebenzisa iimodeli zophando ezinxulumeneyo zibonisa ukuba abantu banokuba neziphumo zonyango ezifanayo okanye iziphumo. njengeempuku.UNjingalwazi uElisabet Jerlhag uthi, kambe ke, kukho umahluko phakathi kohlolisiso olwenziwe kwizilwanyana nakubantu, yaye abaphandi bamele bahlale bewuqwalasela lo mahluko;Kule meko, nangona kunjalo, uphononongo lwangaphambili ebantwini lubonise ukuba uhlobo oludala lwechiza lesifo seswekile elisebenza kwi-GLP-1 lafunyaniswa linciphisa ukuselwa kotywala kubantu abatyebe kakhulu abaxhomekeke etywaleni.
Uphononongo lwangoku luphinde lwaphonononga ukuba kutheni i-somallutide yeziyobisi inciphisa ukusetyenziswa kotywala komntu ngamnye, iphakamisa ukuba ukunciphisa imivuzo yengqondo ebangelwa butywala kunye nezohlwayo kunokuba negalelo;Kwiphepha, abaphandi bafumanisa ukuba ichaphazela umvuzo kunye nenkqubo yesohlwayo sengqondo yegundane.Ngokukodwa ngakumbi, ichaphazela indawo ye-nucleus accumbens, eyinxalenye yenkqubo ye-limbic.Abaphandi bakholelwa ukuba utywala busebenza inkqubo yomvuzo kunye nesohlwayo sengqondo, nto leyo ekhokelela ekukhululweni kwe-dopamine, enokubonwa ebantwini nakwizilwanyana, kwaye le nkqubo ivaliwe emva kokuba iimpuku zinyangwe, ezinokukhokelela kumvuzo omncinci obangelwa butywala kwaye isohlwayo emzimbeni, abaphandi bakholelwa.
Ukuqukumbela, iziphumo zolu phononongo zibonisa ukuba i-somallutide inokunciphisa indlela yokuziphatha yokusela utywala, enokuthi ixoxwe kukuncitshiswa komvuzo obangelwa butywala / indlela yokohlwaya kunye nendlela ye-nucleus accumbens."Njengoko i-somallutide ikwanciphisa ubunzima bomzimba kuzo zombini izini zeempuku zokusela utywala, izifundo zeklinikhi ezizayo ziya kuvavanya ukusebenza kwe-somallutide ekunciphiseni ukusela utywala kunye nobunzima bomzimba kwizigulana ezityebileyo ezinengxaki yokusebenzisa utywala."
Ixesha lokuposa: Nov-07-2023