Iipeptide ezingena kwiseli ziipeptides ezincinci ezinokungena lula kwinwebu yeseli.Olu didi lweeamolekyu, ngakumbi ii-CPPs ezinemisebenzi ekujoliswe kuyo, zinesithembiso sokuhanjiswa kweziyobisi ngokufanelekileyo kwiiseli ezijoliswe kuzo.
Ke ngoko, uphando malunga nalo lunentsingiselo ethile ye-biomedical.Kulo cwaningo, ii-CPPs ezinemisebenzi eyahlukeneyo ye-transmembrane zafundwa kwinqanaba lokulandelelana, ukuzama ukufumana izinto ezichaphazela umsebenzi we-transmembrane we-CPPs, ukuhlukana kokulandelelana phakathi kwe-CPP kunye nemisebenzi eyahlukeneyo kunye ne-NonCPPs, kwaye yazisa indlela yokuhlalutya ukulandelelana kwezinto eziphilayo.
Ii-CPP kunye nee-NonCPP ezilandelelanayo zifunyenwe kwi-database ye-CPPsite kunye neencwadi ezahlukeneyo, kunye ne-transmembrane peptides (i-HCPPs, i-MCPPs, i-LCPPs) kunye nomsebenzi ophezulu, ophakathi, kunye nophantsi we-transmembrane zikhutshwe kwii-CPPs zokulandelelana ukwakha iisethi zedatha.Ngokusekelwe kwezi seti zedatha, ezi zifundo zilandelayo zenziwe:
I-1, i-amino acid kunye nokubunjwa kwesakhiwo sesibini seeCPP ezahlukeneyo ezisebenzayo kunye ne-NonCPPs zahlalutywa yi-ANOVA.Kwafunyaniswa ukuba i-electrostatic kunye ne-hydrophobic interactions ye-amino acids idlala indima ebalulekileyo kumsebenzi we-transmembrane we-CPPs, kunye nesakhiwo se-helical kunye ne-coiling random nayo yachaphazela umsebenzi we-transmembrane we-CPPs.
2. Iimpawu ezibonakalayo kunye neekhemikhali kunye nobude be-CPPs kunye nemisebenzi eyahlukeneyo yaboniswa kwi-plane-dimensional plane.Kwafunyaniswa ukuba ii-CPP kunye nee-NonCPP ezinemisebenzi eyahlukeneyo zinokudityaniswa phantsi kweepropati ezithile ezikhethekileyo, kwaye ii-HCPP, ii-MCPP, ii-LCPP kunye nee-NonCPPs zahlulwe zaba ngamaqela amathathu, zibonisa ukungafani kwazo;
3. Kweli phepha, ingcamango ye-physical and chemical centroid ye-biological sequence iqaliswa, kwaye ii-residus ezenza ulandelelwano zithathwa njengezinto ezincinci, kwaye ulandelelwano lukhutshwe njengenkqubo ye-particle yophando.Le ndlela isetyenziswe kuhlalutyo lwee-CPP ngokubonisa ii-CPPs kunye nemisebenzi eyahlukeneyo kwi-plane ye-3D nge-PCA indlela, kwaye kwafunyaniswa ukuba ezininzi ii-CPP zidibene kunye kunye nezinye ii-LCPP ezidibeneyo kunye ne-NonCPPs.
Olu pho nonongo lunempembelelo ekuyilweni kwee-CPP kunye nokuqonda ukungafani kokulandelelana kwee-CPP kunye nemisebenzi eyahlukeneyo.Ukongeza, indlela yokuhlalutya ye-centroid yomzimba kunye neekhemikhali ze-biological sequences eziziswe kweli phepha nazo zingasetyenziselwa uhlalutyo lwezinye iingxaki zebhayoloji.Kwangaxeshanye, zisenokusetyenziswa njengeeparamitha zegalelo kwiingxaki ezithile zohlelo lwebhayoloji kwaye zidlale indima ekuqatshelweni kwepateni.
Ixesha lokuposa: Jun-15-2023